We are interested in understanding the structural basis of macromolecular assemblies in their functional context. The lab utilizes structural imaging methods, in combination with molecular and biochemical approaches, to study the structure and regulation of macromolecular complexes and organelles in cells. The integrated information provides unique insights into the functional mechanisms of macromolecular assemblies and sub-cellular organelles. Our current projects focus on the cilia of epithelial cells for sensing and responding to extracellular environmental changes.
