Typhanye V. Dyer's research interests include exploring social, cultural and structural determinants of infectious disease disparities. Specifically, her research explores HIV/AIDS disparities, sexuality, mental health, and substance use with an emphasis in racial/ethnic and gender disparities among marginalized populations, as well as their families. Her research in HIV/AIDS also examines theory of syndemic production and HIV risk and prevalence among Black men who have sex with men (BMSM) and Black men who have sex with men and women (BMSMW), and how sex and drug risk networks of MSMW translates into risk for their male and female partners.